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Mvura-Soluble Quercetin ye Superior Nutrient Delivery
Mvura-Soluble Quercetin: Kuvandudza Bioavailability uye Kupayona Nguva Itsva Yehutano.
Quercetin, musanganiswa weflavonoid unowanikwa mukudya kwakasiyana-siyana kwezvirimwa zvakaita sehanyanisi, maapuro, uye michero, yagara iri nzvimbo yakanangana nekutsvaga kwesainzi uye nhaurirano dzehutano, nekuda kweiyo ine simba antioxidant, anti-kuzvimba, uye zvimwe zvakasiyana zvipenyu zviitiko. Nekudaro, kunyungudika kwayo kwemvura kunokanganisa zvakanyanya kunyura uye kushandiswa mukati memuviri wemunhu, nekudaro zvichidzikamisa kuzadzikiswa kuzere kwehutano hwayo. Mumakore achangopfuura, nekuenderera mberi kufambira mberi kwesainzi uye tekinoroji, quercetin inonyungudika nemvura yakabuda, ichikunda matambudziko ekunyungudika echinyakare quercetin uye ichipa huwandu hwakawanda hwekushandisa uye zvakasarudzika zvakanakira.
Revolutionizing Bioavailability: Kukunda Kubvisa Zvipingamupinyi
Traditional quercetin, nekuda kwekudzika kwayo kwemvura kunyungudika, inonetseka kunyungudika mudumbu remudumbu mushure mekutonga nemuromo, zvichikonzera kuderera kwakanyanya. Tsvagiridzo inoratidza kuti intestinal absorption rate inongosvika 2%. Kusiyana neizvi, mvura-inonyungudika quercetin inosimudzira tekinoroji, senge nanomicelle tekinoroji uye cyclodextrin inclusion tekinoroji, kuvandudza zvinoshamisa kunyungudika kwayo mumvura. Semuyenzaniso, iyo Dryland New Materials Laboratory yeSouth Subtropical Crops Research Institute, Chinese Academy yeTropical Agricultural Sayenzi, yakabudirira kugadzirira quercetin-yakatakura nanomicelles kuburikidza nemakemikari ekubatanidza nzira. Uku kutsva kwakawedzera zvakanyanya kunyungudika kwemvura yequercetin, kutaridzika kwemifananidzo, uye kugona kweserura. Nekuda kweizvozvo, quercetin inogona kunyungudika zvakanyanya mumvura yemudumbu, ichiwedzera nzvimbo yayo yekusangana nemaseru emukati mucosal maseru uye kuwedzera zvakanyanya kunyura kwayo mumuviri wemunhu. Zvidzidzo zvakakodzera zvinoratidza kuti bioavailability yequercetin inonyungudika mumvura inogona kuwedzerwa kakawanda kana kupfuura kana ichienzaniswa neyechinyakare quercetin, zvichiita kuti muviri utore zvirinani uye ushandise zvikamu zvinoshanda zvequercetin uye kuvhura zvizere mhedzisiro yayo yekusimudzira hutano.
Zvikumbiro Zvehutano zvakasiyana
1. Ropa Glucose Regulation
Mvura-soluble quercetin inopa tariro itsva kune vanhu vane hanya nehutano hweglucose yeropa. Tsvagiridzo yakaitwa neZhengzhou Fruit Research Institute, Chinese Academy of Agricultural Sciences, yakaratidza kuti quercetin, pamwe chete nemimwe michero flavonoids, inogona synergistically inhibisa basa rea-glucosidase. α-Glucosidase inoita basa rakakosha muhydrolysis yemakhahydrates, uye kuvharidzira kuita kwayo kunogona kunyatso kuvharira kugayiwa uye kunyura kwemacarbohydrates, nekudaro zvichibatsira kudzora postprandial mazinga eglucose eropa. Nekunyungudika kwayo kwakanakisa uye kunyura, mvura-inonyungudika quercetin inogona kunyatsotora chikamu mukuvharirwa kwe-α-glucosidase, ichipa rutsigiro rwakasimba rwekugadzirwa kwezvinhu zvinoshanda zvine chinangwa chekugadzirisa postprandial yeropa glucose. Izvi zvine zvazvinoreva kune manejimendi ehutano hwemazuva ese evarwere vane chirwere cheshuga kana avo vane mazinga eropa anochinja.
2. Chiropa Chekuchengetedza Utano
Mvura-soluble quercetin inopenyawo mukuchengetedza hutano hwechiropa. Ongororo yakaitwa nechikwata chaProfessor Peng Cheng kubva kuChengdu University yeTraditional Chinese Medicine yakaratidza kuti quercetin inokwanisa kugadzirisa chiropa chine mafuta edoro nekuyananisa kutamiswa kwenyukireya kweTFEB kuripa kusakwana kwe autophagy. Iyo inowedzerwa kunyura kwemvura-soluble quercetin inobvumira kuti isvike pachiropa nekukurumidza uye zvinobudirira, kusimbisa autophagic basa remasero echiropa, kukurudzira metabolism yemafuta mukati mechiropa, uye kufambisa kubviswa kwezvinhu zvinokuvadza. Izvi zvinobatsira kudzivirira uye kuvandudza zvirwere zvakasiyana-siyana zvechiropa, zvakadai semafuta ane chiropa uye chirwere chedoro chechiropa, nekuderedza kukuvadzwa kunokonzerwa nedoro nezvimwe zvinhu kune chiropa.
3. Bvudzi Regeneration Kukurudzira
Kurasika kwebvudzi chinhu chinowanzoitika kune vanhu vazhinji, uye quercetin inonyungudika nemvura inopa mhinduro nyowani padambudziko iri. Ongororo yemubatanidzwa yakaitwa nechikwata chaProfessor Qu Jing kubva kuInstitute of Zoology, Chinese Academy of Sciences, yakaona kuti quercetin inogona kusimudzira kumerazve kwebvudzi nekuita iyo HIF-1 nzira muendothelial masero ebvudzi follicle microenvironment. Mvura-soluble quercetin inogona kunyanya kupinda muropa uye inosvika kunzvimbo yebvudzi rebvudzi, ichiita zvizere maitiro ayo ekugadzirisa pane bvudzi follicle microenvironment. Inokurudzira kusiyanisa uye kupararira kwebvudzi follicle stem masero, nokudaro kukurudzira kukura kwebvudzi. Kunyangwe kurasikirwa kwebvudzi kunokonzerwa nekushushikana, kusaenzana kwehomoni, kana zvimwe zvinhu, mvura-soluble quercetin inobata vimbiso seyakachengeteka uye inoshanda adjuvant kurapwa.
4. Kuwedzera kweImmune System
Quercetin pachayo ine mamwe immunomodulatory zviitiko, sekusimudzira macrophage activation uye kuvanzika kweakabatana immune factor. Kuuya kwequercetin inonyungudika nemvura kunowedzera zvakanakira izvi. Kunyungudika kwayo kwemvura kunogonesa kugovaniswa kwakafanana mukati memuviri, zvichiita kuti iite zvakanyatsoita pazvikamu zvakasiyana zve immune system. Inosimudzira basa remasero ekudzivirira uye inosimudzira kuvharirwa kwezvidziviriro zvemuviri senge tumor necrosis factor-α uye interferon-γ, zvichibatsira muviri kudzivirira zviri nani kurwisa hutachiona hwekunze uye zvakanyanya kuwedzera hutachiona hwese. Izvi zvinopa vanhu simba rekuti varambe vakasimba kana vakatarisana nenjodzi dzehutano dzakadai sehutachiona hwefuruwenza uye hutachiona hwehutachiona.
Kuchengetedzwa Profile uye Ramangwana Tarisiro
Kugadzirira kwequercetin inonyungudika nemvura kunonyanya kushandisa nzira dzakachengeteka uye dzakagadzikana, dzakadai seye nanomiclle tekinoroji yambotaurwa. Idzi nzira dzinovandudza kunyungudika kwemvura yequercetin pasina kuunza makemikari anokuvadza, kuve nechokwadi chekuchengetedzwa kwechigadzirwa. Zvakare, nekuda kwekuwedzera kwayo bioavailability, yakaderera dosi ye quercetin inodiwa kuti uwane iwo mabhenefiti ehutano, zvichiwedzera kudzikisira njodzi yekukonzeresa kwakashata.
Nekuenderera mberi nekudzika kwekutsvagisa uye nekuenderera mberi hunyanzvi hwetekinoroji, mvura-inonyungudika quercetin yagadzirira kuratidza kunyange yakakura yekushandisa inogona mukudya zvinoshanda, chikafu chekuwedzera, cosmetics, uye indasitiri yemishonga. Munzvimbo yezvikafu zvinoshanda, zvinogona kuiswa muzvinwiwa zvakasiyana-siyana uye svutugadzike, zvichipa vatengi kuchengetedzwa kwehutano kuri nyore. Muindasitiri yezvizorwa, kukwirisa bvudzi rayo-kugadziridza uye antioxidant zvimiro, zvigadzirwa zvine mabasa akadai se-anti-bvudzi kurasikirwa uye anti-ganda kuchembera zvinogona kuvandudzwa. Mundima yemishonga, pane vimbiso huru yekuenderera mberi nekuongorora mashandisiro ayo mukurapa zvirwere zvisingaperi uye kubatsira mukurapa kwemishonga, kuvhura mahorizoni matsva ezvekurapa uye hutano tsvakurudzo.
References
1.South Subtropical Crops Research Institute, Chinese Academy yeTropical Agricultural Sciences. (nd). Hutsva Hutsva muNano Yakasimudzwa-Kuburitsa Zvinodhaka Inotakura Zvishandiso. Yakadzorerwa kubva ku http://m.toutiao.com/group/7164215338974839308/?upstream_biz=doubao
2.Peng, C., nevamwe. (nd). Quercetin inoderedza ethanol - induced hepatic steatosis muL02 masero nekuita TFEB translocation kutsiva kusakwana autophagy. PHYTOTHERAPY RESEARCH (Second Category in Chinese Academy of Sciences). Zvakatorwa kubva mumadhatabheti ezvidzidzo
3.Qu, J., nevamwe. (nd). Single - cell Profileing Inoburitsa Basa Rine Simba reQuercetin Mukusimudzira Kuvandudzwa Kwebvudzi. Mapuroteni & Sero. Yakadzorerwa kubva https://m.thepaper.cn/newsDetail_forward_21318679
4.Jin, Z., nevamwe. (2024). Co-encapsulation ye quercetin uye resveratrol: Kuenzanisa muzvikamu zvakasiyana zve zein - carboxymethyl cellulose nanoparticles. International Journal yeBiological Macromolecules, 263, Chinyorwa 127439. https://doi.org/10.1016/j.ijbiomac.2024.127439
5.Zhengzhou Fruit Research Institute, Chinese Academy of Agricultural Sciences. (2024). Flavonoids muMichero Regulate Postprandial Ropa Glucose. Yakadzorerwa kubva ku http://www.xinhuanet.com/science/20241105/c730eb7ee20a4e0ab8d2ec96570044ca/c.html
