Murwendo rwekutsvaga hutano nekunonoka kuchembera, tsvakiridzo yesainzi inogara ichitiunzira tariro itsva nemikana. Mumakore achangopfuura, NMN (Nicotinamide Mononucleotide), chinhu chinotariswa zvakanyanya bioactive, yakauya zvishoma nezvishoma muziso revanhu uye yakakwezva kutarisisa kwakapararira. Chii chaizvo? Uye nei zvakakonzera kupenga kwakadaro mumunda wehutano? Ngationgororei zvakavanzika zveNMN pamwe chete.
●NMN chii?
NMN, inonzi Nicotinamide Mononucleotide, imorekuru rinogara riripo mumarudzi ese ehupenyu. Mumuviri wemunhu, NMN ndiyo kiyi inofanotungamira kune synthesis ye coenzyme I (NAD +). Coenzyme I (NAD +) inotora chikamu mukuita kwakawanda kwakakosha kwemetabolism mukati memasero uye inoita basa rakakosha mukuchengetedza mabasa akajairwa uye simba remasero. Sezvo vanhu vachikura, mwero weNAD + mumuviri wemunhu unodzikira zvishoma nezvishoma, izvo zvinotendwa kuti zvine hukama neshanduko dzakawanda dzemuviri dzine chekuita nekuchembera uye kuitika uye kukura kwezvirwere. Kuwedzera neNMN kunogona kunyatso kuwedzera zvirimo zveNAD+ mumuviri, nekudaro zvichipa tsigiro yakakwana yesimba rekushanda kwesero uye kubatsira kuchengetedza hudiki hwemuviri..
●Nheyo yekushanda yeNMN
Iyo nzira yekuita yeNMN inonyanya kutenderera nekukwira kwayo kweNAD + mazinga. Kana isu tichimedza NMN, inokurumidza kutorwa nemuviri uye inoshandurwa kuita NAD + pasi pekuita kweakatevedzana ma enzymes. Se coenzyme yemazhinji ma enzymes akakosha, NAD + inotora chikamu mune akakosha maitiro emuviri mukati memasero, senge simba metabolism, kugadzirisa kweDNA, uye gene expression regulation. Panyaya yesimba remetabolism, NAD + inobatanidzwa mukuita kwekufema kweserura, kubatsira mitochondria kushandura chikafu kuita ATP, iyo molecule yesimba iyo maseru anogona kushandisa zvakananga. Yakakwana NAD + mazinga anobatsira mukuvandudza mashandiro uye kugona kwemitochondria, ichipa simba rakawanda kumaseru uye kutiita kuti tive nesimba rakawanda uye simba. Muchikamu chekugadzirisa DNA, NAD+ yakakosha substrate yemhuri yePARP (Poly ADP - Ribose Polymerase). Kana maseru akuvadzwa ne ultraviolet rays, oxidative stress, nezvimwewo, PARP ma enzymes anobatiswa uye anoshandisa NAD + kugadzira PAR (Poly ADP - Ribose), uyezve kutora mapuroteni ane hukama kugadzirisa DNA yakakanganisika. Kuchengeta huwandu hwepamusoro hweNAD + kunogona kuwedzera basa rePARP enzymes, kukurumidza kugadzirisa DNA, kuderedza kuunganidzwa kwemajini ekuchinja uye kukuvara kwesero, uye kubatsira kudzivirira kuitika kwekuchembera - hosha dzine hukama. Uye zvakare, NAD + inobatanidzwawo mukugadzirisa kweSirtuins protein yemhuri. Sirtuins mapuroteni anoita mabasa anokosha mukukwegura kwesero, metabolic regulation, inflammatory responses, etc. Sezvo coenzyme yeSirtuins, NAD + inogona kushandura maSirtuins mapuroteni, kugadzirisa gene expression, uye kukanganisa mabasa ehupenyu uye hupenyu hwemasero. Nekuwedzera NMN kuwedzera mazinga eNAD +, inogona kuita zvisina kunanga maSirtuins mapuroteni uye kuita mabasa akadai sekunonoka kuchembera kwesero uye kuvandudza metabolic basa.
●Kushanda kweNMN
1: Kunonoka senescence
Iyo nzira yekuchembera inoperekedzwa nekuderera zvishoma nezvishoma kwemabasa enhengo dzakasiyana siyana uye masisitimu mumuviri. NMN inononotsa kuchembera padanho remaserura kuburikidza nenzira dzakawanda dzakadai sekuwedzera NAD + mazinga, kuvandudza mitochondrial basa, kuwedzera DNA kugadzirisa kugona, uye activate Sirtuins mapuroteni. Tsvagiridzo inoratidza kuti kuwedzera neNMN kunogona kuvandudza zvakanyanya mashandiro emuviri emhuka dzekuyedza, sekusimudzira simba remhasuru, kuvandudza kutsungirira kwekurovedza muviri, uye kuwedzera kugona kwekuziva, kuita kuti varatidzike uye vazvibate vari vadiki. Kune vanhu, kuwedzerwa kwenguva refu neNMN kunotarisirwawo kunonoka kukwegura kweganda, kuderedza kutaridzika kwemakwinya uye mavara ezera, kunatsiridza hutano hwekurara, uye kuwedzera hutano hwese hwemuviri, zvichiita kuti tichengetedze kunaka uye simba.
2: Kuwedzera kusadzivirirwa
NMN ine yakanaka kudzora maitiro pane immune system. Kune rimwe divi, inogona kusimudzira kuwanda nekusiyaniswa kwemasero edziviriro, kuwedzera basa remasero edziviriro, nekuvandudza kugona kwemuviri kupindura. Kune rimwe divi, NMN inobatsira kuchengetedza yakajairika basa remitochondria mumasero edziviriro, ichipa simba rakakwana retsigiro yezviitwa zvemasero emuviri. Nekuwedzera neNMN, tinokwanisa kuwedzera kusadzivirirwa kwedu pachedu, kuderedza njodzi yehurwere, uye kurarama zvirinani nematambudziko ekunze.
3:Kuvandudza metabolic basa
Metabolic dysfunction ndiyo inokonzera zvirwere zvakawanda zvisingaperi, zvakadai sokufutisa, chirwere cheshuga, zvirwere zvemwoyo, nezvimwewo. NMN inogona kuvandudza metabolic basa nekugadzirisa metabolic nzira mukati memasero. Tsvagiridzo yakawana kuti kuwedzera neNMN kunogona kuwedzera insulin senitivity, kukurudzira kutora uye kushandiswa kweglucose, uye kubatsira kuchengetedza kugadzikana kweshuga yeropa. Panguva imwecheteyo, NMN inogonawo kuwedzera mafuta metabolism, kuderedza kuunganidzwa kwemafuta mumuviri, uye kuita basa rakanaka mukudzivirira nekuvandudza kufutisa. Mukuwedzera, NMN ine simba rekudzivirira pamwoyo. Inogona kuderedza ropa lipid mazinga, kunatsiridza vascular endothelial basa, uye kuderedza njodzi yezvirwere zvemoyo. Kune avo vane hanya nezvehutano hwemetabolism, NMN pasina mubvunzo ndeyekudya kunovaka muviri pamwe nekukosha kwakawanda.
4:Kuvandudza basa rekuziva
Nekukura kwezera, kushanda kwehuropi zvishoma nezvishoma kunoderera, kuderera kwendangariro, kusagadzikana kwekuziva uye mamwe matambudziko anowedzera kunetsa vakwegura. NMN yakaratidza mhedzisiro inovimbisa mukuvandudza kugona kwekuziva.
Contact:Judy Guo
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Nguva yekutumira: Mar-29-2025