● Chii chinonzi urolixin A
Urolithin A (yakapfupikiswa seUA) ndeye yakasikwa polyphenol komboni inogadzirwa ne intestinal microbiota metabolism ye ellagitannins. Ellagitannins inowanikwa zvakanyanya muzvokudya zvakadai semapomegranati, sitirobheri, raspberries, walnuts, uye waini tsvuku. Kana vanhu vakadya zvikafu izvi, iyo ellagitannins inoshandurwa kuita urolithin A neiyo hutachiona huzhinji huri muura.
● Zvinhu zvakakosha zveurolithin A
Zita reChirungu: Urolithin A
CAS nhamba: 1143-70-0
Molecular fomu. : C₁₃H₈O₄
Huremu hwemorekuru: 228.2
Chitarisiko: Yellow kana light yellow solid powder
● Bioactivity uye kushanda zvakanaka kweurolixin A
1:Anti-aging effect
Kuvandudza mitochondrial basa: urolithin A inogona kukurudzira mitophagy, kubatsira kujekesa mitochondria yakakuvadzwa, kukurudzira chizvarwa chemitochondria itsva, inoshanda, kuitira kuchengetedza simba remetabolism yemasero uye kunonoka kukwegura.
2:Neuroprotective effect
Deredzai neuroinflammation: Urolitin A inogona kuyambuka ropa-brain barrier, kuderedza amyloid beta (Aβ) uye tau protein lesions, uye inokonzera mitochondrial autophagy, nokudaro inovandudza zviratidzo zvezvirwere zveurourodegenerative zvakadai seAlzheimer's disease uye Parkinson's disease.Kuvandudza chiyeuchidzo chekushanda: Zvidzidzo zvakaratidza kuti urolixin yekudzidza, chiyeuchidzo mu olf inogona kuvandudza zvikuru basa rekudzidza, chiyeuchidzo uye mitoo.
3:Muscular protection
Kuwedzera simba remasumbu uye kutsungirira: Urolixin A inogona kuvandudza hutano hwemasumbu, kuwedzera simba remasumbu uye kutsungirira, uye ine mukana wekupindira mune zvirwere zvine muscular dystrophy.Inosimudzira kupora kwemhasuru: Nekugadzirisa nzira dzakadai semitochondrial basa mukati memasero emasumbu, urolixin A inobatsira vakwegura kana vanhu vane matambudziko ekufambisa nekuda kwechirwere kuti vaite basa rinodiwa uye kukurudzira musimba kupora.
4:Anti-inflammatory effect
Kudzivirirwa kwezvinhu zvinoputika: urolithin A inogona kudzivisa kugadzirwa uye kusunungurwa kwezvinhu zvinoputika zvakadai seIL-6 uye TNF-α, uye kuderedza kuputika kwechirwere.
5:antioxidation
Kutsvaira mahara radicals: Urolixin A ine simba rekubvisa zvakananga mahara radicals uye kuderedza kukuvadzwa kweiyo oxidative kusagadzikana pamasero.Enhance antioxidant kudzivirira: Urolixin A inogona kuwedzera endogenous antioxidant kudzivirirwa kugona kwemasero nekuita iyo Nrf2 antioxidant nzira uye kumusoro-kutonga kutaura kweakasiyana siyana antioxidant enzymes akadai seglutathione super dissease peroximudase.
6:Antitumor effect
Kudzivirirwa kwe tumor cell proliferation: urolixin A inogona kudzivisa kupararira, kupinda uye metastasis yekenza yeprostate, kenza yekoloni uye mamwe masero emudumbu.Induction of tumor cell apoptosis: Nokuita apoptosis-related signaling pathways, urolixin A inogona kukonzera tumor cell apoptosis, nokudaro ichidzivisa kukura kwechirwere.
7:Kuvandudza metabolic zvirwere
Kurongeka kweshuga yeropa uye lipid yeropa: urolithin A inogona kugadzirisa nzira yemuviri wemagetsi uye inobata basa rakanaka pakuvandudza shuga yeropa uye ropa lipid mazinga.Anti-obesity: Nekuita kuti mafuta asvibe kushandiswa uye mafuta machena Browning, urolixin A inogona kukurumidza kukonzera mafuta uye kudzivirira kuunganidza mafuta kunokonzerwa nekudya.
8:Kuvandudza chirwere cheitsvo
Kuderedza kukuvara kwetsvo: Urolixin A inogona kuderedza kukuvara kwetsvo nekuita mitochondrial autophagy yemasero eitsvo, kuderedza collagen kuunganidza, kuderedza fibrocyte kuwedzera kana kuderedza fiber tissue deposition kuti inonoke kukura kwefibrosis process.
● Tarisiro yekushandisa urolithin A
1:Tsvagiridzo yezvinodhaka nekuvandudza
Urolixin A inotarirwa yakakurumbira yekurwisa-kuchembera, neuroprotective, anti-tumor drug development nekuda kwekuita kwayo kwakasiyana-siyana kwezvinhu zvipenyu.Parizvino, Mazhinji emasangano ekutsvagisa uye mabhizinesi atanga kudzidza kugadzirwa kwemishonga yeurolixin A, achitarisira kugadzira mishonga inoshanda uye yakachengeteka.
2:Cosmetics tsvagiridzo nekusimudzira
Iyo antioxidant uye inorwisa-kuzvimba mhedzisiro yeurolixin A inoita kuti ive neyakafara tarisiro yekushandisa mumunda wezvizoro.Nekuwedzera urolixin A, zvizoro zvinogona kuwedzera anti-kuchembera uye kugadzirisa ganda.
3:Tsvakurudzo yezvokudya uye kubudirira
Urolixin A ine mukana wekushandisa kukosha mumunda wekudya nekuda kwemabasa ayo akasiyana-siyana ehupenyu.Nekuwedzera ellagitannin-rich foods kana urolithin A supplements, zvekudya zvinogona kuwedzera mabhenefiti ehutano uye kusangana nezvinodiwa nevatengi zvekudya zvine hutano.
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Nguva yekutumira: Mar-27-2025