Kuunza PQQ: Iyo Yekupedzisira Energy Booster yePfungwa neMuviri

Kuunza PQQ: Iyo Yekupedzisira Energy Booster yePfungwa neMuviri

Pyrroloquinoline quinone, inonzi PQQ, iboka idzva reprosthetic rine mabasa akafanana emuviri kune mavhitaminzi. Inowanikwa zvakanyanya mumaprokaryotes, zvidyarwa uye mhuka dzinoyamwisa, senge soya yakaviriswa kana natto, girinhi mhiripiri, kiwi michero, Parsley, tii, papaya, sipinachi, celery, mukaka waamai, nezvimwe.

Mumakore achangopfuura, PQQ yave imwe ye "nyeredzi" chikafu chakakwezva kutarisisa kwakapararira. Muna 2022 na2023, nyika yangu yakabvumidza PQQ inogadzirwa nekubatanidza uye kuviriswa sezviyo zvitsva zvekudya.

Iwo biological mabasa ePQQ anonyanya kutariswa muzvikamu zviviri. Kutanga, inogona kutsigira kukura uye kukura kwemitochondria uye kukurudzira kukura nokukurumidza kwemasero evanhu; chechipiri, ine yakanaka antioxidant properties, iyo inogona kubatsira kubvisa mahara radicals uye kuderedza kukuvara kwesero. Aya mabasa maviri anoita kuti iite basa rine simba muhutano hwehuropi, hutano hwemoyo, hutano hwemetabolism uye zvimwe zvinhu. Nekuti muviri wemunhu haugone kugadzira PQQ uri wega, inoda kuwedzerwa kuburikidza nekudya kwekuwedzera.

01.PQQ basa rekuvandudza cognition rinonyanya kukoshesa

Muna Kukadzi 2023, vaongorori vekuJapan vakaburitsa bepa rekutsvagisa rakanzi "Pyrroloquinoline quinone disodium munyu inovandudza huropi hunoshanda mune vese vadiki nevakuru vakuru" mumagazini "Chikafu & Basa", vachiunza ruzivo rwePQQ kune vechidiki uye vanhu vakuru muJapan. Zvakavandudzwa zvetsvakiridzo.

Ichi chidzidzo chaive kaviri-bofu placebo randomized controlled trial yaisanganisira 62 varume vane hutano hweJapan vane makore 20-65, vane Mini-Mental State Scale scores ≥ 24, avo vakachengetedza mararamiro avo epakutanga panguva yekudzidza. Mhomho yevakadzi. Zvidzidzo zvekutsvagisa zvakakamurwa zvisina tsarukano kuita boka rekupindira uye boka rekudzora placebo, uye raipihwa nemuromo PQQ (20 mg / d) kana placebo capsules zuva nezuva kwemavhiki e12. Iyo yepamhepo yekuyedza system yakagadziriswa nekambani yakashandiswa kuzivikanwa pamavhiki 0/8/12. Muedzo wekuziva unoongorora zvinotevera gumi neshanu mabasa ehuropi.

Zvigumisiro zvakaratidza kuti zvichienzaniswa neboka rekudzora placebo, mushure memavhiki e12 ePQQ yekudya, chiyeuchidzo chinosanganiswa uye nhamba dzekuyeuka dzemashoko emapoka ose uye boka revakuru rakawedzera; mushure memavhiki masere ekutora kwePQQ, kushanduka kweboka rechidiki, kukurumidza kugadzirisa uye Kuuraya kukurumidza mamakisi kwakawedzera.

02 PQQ haingogone kuvandudza kushanda kwehuropi kwevakweguru, asi zvakare kunatsiridza mhinduro yehuropi hwevechidiki!

Muna Kurume 2023, bepanhau rine mukurumbira pasi rese Food & Function rakaburitsa bepa rekutsvagisa rakanzi "Pyrroloquinoline quinone disodium munyu inovandudza kushanda kwehuropi muvakuru vadiki nevakuru". Ichi chidzidzo chakaongorora maitiro ePQQ pakuita kwekuziva kwevakuru vane makore makumi maviri neshanu, kuwedzera huwandu hwekudzidza hwePQQ kubva kune vakura kuenda kune vechidiki. Chidzidzo ichi chakaratidza kuti PQQ inogona kuvandudza basa rekuziva kwevanhu veese mazera.

Tsvagiridzo yakawana kuti PQQ, sechikafu chinoshanda, inogona kuvandudza kushanda kwehuropi chero zera, uye inotarisirwa kuwedzera kushandiswa kwePQQ sechikafu chinoshanda kubva kune vakura kusvika kuvanhu veese mazera.

03 PQQ inoita se activator ye "sero simba mafekitori" kudzoreredza hutano hwavo

Muna Chivabvu 2023, Cell Death Dis yakaburitsa bepa rekutsvagisa rakanzi Obesity inokanganisa cardiolipin-inotsamira mitophagy uye kurapa intercellular mitochondrial kutamisa kugona kwemesenchymal stem masero. Chidzidzo ichi chakawana PQQ nekuongorora kana iyo intercellular mitochondrial donor kugona yezvidzidzo zvakafuta (vanhu vane metabolic kusagadzikana) uye kurapa kwemesenchymal stem masero (MSCs) haashande, uye kana mitochondrial-yakanangwa kurapa inogona kuidzosera. Modulation inodzoreredza hutano hwemitochondrial kudzikisira kusagadzikana mitophagy.
Ichi chidzidzo chinopa yekutanga yakazara mamorekuru kunzwisisa kwekukanganiswa mitophagy mune kufutisa-yakatorwa mesenchymal stem maseru uye inoratidza kuti hutano hwemitochondrial hunogona kudzoreredzwa kuburikidza nePQQ mutemo kudzikisa kukanganisa mitophagy.

04 PQQ inogona kuvandudza metabolic basa remunhu

Muna Chivabvu 2023, chinyorwa chekuongorora chakanzi "Pyrroloquinoline-quinone kuderedza kuunganidzwa kwemafuta uye kuwedzera kufutisa" yakabudiswa mupepanhau Front Mol Biosci, iyo yakapfupisa zvidzidzo zvemhuka zvishanu uye zvidzidzo zviviri zvemasero.
Mhedzisiro yacho inoratidza kuti PQQ inogona kuderedza mafuta emuviri, kunyanya visceral uye chiropa kuunganidza mafuta, nekudaro kudzivirira kufutisa kwechikafu. Kubva pakuongororwa kwemusimboti, PQQ inonyanya kurambidza lipogenesis uye inoderedza kuunganidzwa kwemafuta nekuvandudza mitochondrial basa uye kusimudzira lipid metabolism.

05 PQQ inogona kudzivirira osteoporosis inokonzerwa nekuchembera chaiko

MunaGunyana 2023, Aging Cell yakaburitsa bepa rekutsvagisa rakanzi "Pyrroloquinoline quinone inoderedza kuchembera kwakabatana neosteoporosis kuburikidza neinoveli MCM3-Keap1-Nrf2 axis-mediated stress response uye Fbn1 upregulation" online. Chidzidzo ichi, kuburikidza nekuyedza pamakonzo, chakawana kuti chikafu chePQQ chekuwedzera chinogona kudzivirira osteoporosis inokonzerwa nekuchembera kwechisikigo. Iyo yepasi meshini yePQQ ine simba antioxidant simba inopa hwaro hwekuyedza hwekushandiswa kwePQQ sechikafu chekuwedzera kudzivirira kwezera rine chekuita neosteoporosis.
Ichi chidzidzo chinoburitsa basa rinoshanda uye nzira nyowani yePQQ mukudzivirira nekurapa senile osteoporosis, uye inoratidza kuti PQQ inogona kushandiswa seyakachengetedzeka uye inoshanda yekuwedzera chikafu kudzivirira nekurapa senile osteoporosis. Panguva imwecheteyo, zvakaratidzwa kuti PQQ inomutsa iyo MCM3-Keap1-Nrf2 chiratidzo mune osteoblasts, transcriptally inosimudzira kutaura kwe antioxidant genes uye Fbn1 genes, inhibits oxidative kusagadzikana uye osteoclast bone resorption, uye inosimudzira osteoblast bone kugadzirwa, nekudaro kudzivirira kuchembera. basa mukuitika kwepabonde osteoporosis.

06 Kuwedzera PQQ kunogona kuchengetedza retinal ganglion masero uye kunatsiridza hutano hwemaziso!

MunaGunyana 2023, magazini inonzi Acta Neuropathol Commun yakaburitsa chidzidzo kubva kune nyanzvi dzeophthalmology uye nyanzvi kubva kuEye Hospital yeKarolinska Institutet muStockholm, Sweden, chikoro chakakurumbira chekurapa chekuEurope, pamwe neRoyal Victoria Eye uye Ear Hospital muAustralia, uye Dhipatimendi reBiology yeYunivhesiti yePisa muItaly. Inonzi "Pyrroloquinoline quinone inotyaira ATP synthesis in vitro uye in vivo uye inopa retinal ganglion cell neuroprotection." Tsvagiridzo yakaratidza kuti PQQ ine mhedzisiro yekudzivirira pane retinal ganglion masero (RGC) uye ine hukuru hukuru senge neuroprotective mumiriri mukuramba retinal ganglion cell apoptosis.
Zvakawanikwa zvinotsigira iro rinogona kuita basa rePQQ seyakaonekwa neuroprotective agent iyo inogona kuvandudza kusimba kweretinal ganglion masero uku ichidzikisa njodzi yezvinobvira mhedzisiro. Panguva imwecheteyo, vaongorori vanotenda kuti kuwedzera PQQ isarudzo inoshanda yekuchengetedza hutano hwemaziso.

07 Kuwedzera PQQ kunogona kudzora maruva emudumbu, kunatsiridza kushanda kwethyroid, uye kuderedza kukuvara kwehuro.

Muna Zvita 2023, timu yekutsvagisa kubva kuShanghai Tenth People's Hospital yeTongji University Chikoro cheMishonga yakaburitsa chinyorwa chakanzi "Iyo Inogoneka Basa rePyrroloquinoline Quinone Kudzora Thyroid Basa uye Gut Microbiota Kuumbwa kweChirwere cheMakuva muMbeva" mujenari Pol J Microbiol Muchinyorwa ichi, vaongorori vakashandisa regulate mbeva muQQ mumuenzaniso kuderedza kukuvara kwematumbo, uye kuvandudza thyroid basa.
Chidzidzo ichi chakawana mhedzisiro yePQQ yekuwedzera pane GD mbeva uye maruva emudumbu:

01 Mushure mekuwedzera kwePQQ, serum TSHR uye T4 yeGD mice yakaderedzwa, uye ukuru hwetachiona gland hwakaderedzwa zvakanyanya.

02 PQQ inoderedza kuzvimba uye oxidative kusagadzikana, uye inoderedza diki intestinal epithelial kukuvara.

03 PQQ ine mhedzisiro yakakosha pakudzoreredza kusiyanisa uye kuumbwa kwemicrobiota.

04 Kuenzaniswa neboka reGD, kurapwa kwePQQ kunogona kuderedza kuwanda kweLactobacilli mumakonzo (iyi ndiyo inogona kutariswa kurapa kweGD maitiro).

Muchidimbu, PQQ yekuwedzera inogona kudzora thyroid basa, kuderedza kukuvadzwa kwethyroid, uye kuderedza kuzvimba uye oxidative kusagadzikana, nekudaro kudzikisa diki intestinal epithelial kukuvara. Uye PQQ inogona zvakare kudzoreredza kusiyanisa kwemaruva emukati.

Pamusoro pezvidzidzo zviri pamusoro zvinoratidza basa rakakosha uye risingaperi kugona kwePQQ sechikafu chekuwedzera hutano hwevanhu, zvidzidzo zvekare zvakaramba zvichisimbisa mabasa ane simba ePQQ.

08 PQQ inogona kuvandudza pulmonary hypertension

Muna Gumiguru 2022, bepa rekutsvagisa rakanzi "Pyrroloquinoline quinone (PQQ) inovandudza pulmonary hypertension nekudzora mitochondrial uye metabolic mabasa" rakaburitswa mupepanhau rePulmonary Pharmacology & Therapeutics, nechinangwa chekuongorora basa rePQQ mukuvandudza pulmonary hypertension.
Mhedzisiro yacho inoratidza kuti PQQ inogona kuderedza mitochondrial abnormalities uye metabolic abnormalities mupulmonary artery yakatsetseka mhasuru maseru uye kunonoka kufambira mberi kwepulmonary hypertension mumakonzo; saka, PQQ inogona kushandiswa seanogona kurapa mumiririri kuvandudza pulmonary hypertension.

09 PQQ inogona kunonoka kuchembera kwesero uye kuwedzera hupenyu!

Muna Ndira 2020, bepa rekutsvagisa rakanzi Pyrroloquinoline quinone inonoke kuzvimba kunokonzerwa neTNF-α kuburikidza nep16/p21 uye Jagged1 nzira dzekusaina dzakaburitswa muClin Exp Pharmacol Physiol yakanyatso simbisa iyo anti-kuchembera mhedzisiro yePQQ mumasero emunhu. , mhedzisiro inoratidza kuti PQQ inononoka kuchembera kwesero remunhu uye inogona kuwedzera hupenyu.

Vatsvagiri vakaona kuti PQQ inogona kunonoka kuchembera kwesero remunhu, uye yakasimbisa mhedzisiro iyi kuburikidza nemhedzisiro yekutaura kweakawanda biomarker senge p21, p16, uye Jagged1. Zvinokurudzirwa kuti PQQ inogona kuvandudza hutano hwese hwehuwandu uye kuwedzera hupenyu hurefu.

10 PQQ inogona kudzivirira kuchembera ovarian uye kuchengetedza kubereka

Muna Kurume 2022, bepa rekutsvagisa rakanzi "PQQ Dietary Supplementation Inodzivirira Alkylating Agent-Induced Ovarian Dysfunction in Mice" rakabudiswa mupepanhau Front Endocrinol, nechinangwa chekudzidza kana PQQ yezvekudya inodzivirira kubva kune alkylating agent-induced ovarian dysfunction. effect.
Mhedzisiro yacho yakaratidza kuti PQQ yekuwedzera yakawedzera huremu uye saizi yemaovari, yakadzoreredza zvishoma yakakanganisika estrous cycle, uye yakadzivirira kurasikirwa kwemafollicles mumakonzo akabatwa nealkylating agents. Uyezve, PQQ yekuwedzera yakawedzera zvakanyanya chiyero chekuzvitakura uye saizi yemarara pakusununguka mune alkylating agent-yakarapwa mbeva. Mhedzisiro iyi inosimbisa kugona kwekupindira kwePQQ yekuwedzera mune alkylating agent-induced ovarian dysfunction.

Mhedziso
Muchokwadi, sechikafu chitsva chekuwedzera, PQQ yave kuzivikanwa nekuda kwemaitiro ayo akanaka pakudya uye hutano. Nekuda kwemabasa ayo ane simba, kuchengetedzwa kwepamusoro uye kugadzikana kwakanaka, ine tarisiro yakakura yekusimudzira mumunda wezvikafu zvinoshanda.
Mumakore achangopfuura, nekudzika kwezivo, PQQ yakawana certification yakakwana yekushanda uye inoshandiswa zvakanyanya sechikafu chekuwedzera kana chikafu muUnited States, Europe nedzimwe nyika nematunhu. Sezvo kuziva kwevatengi vepamba kuri kuramba kuchidzika, zvinotendwa kuti PQQ, sechinhu chitsva chekudya, ichagadzira nyika nyowani mumusika wepamba.

References:

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